Dysregulation of mTOR signalling is a converging mechanism in lissencephaly – Nature

Nature, Published online: 01 January 2025; doi:10.1038/s41586-024-08341-9

Cellular, transcriptomic and proteomic analyses of organoids derived from human induced pluripotent stem cells show that mTOR pathway hypoactivation is involved in two genetically distinct lissencephaly spectrum disorders.