Organ-specific sympathetic innervation defines visceral functions – Nature

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  • Langley, J. N. The Autonomic Nervous System (Pt. I) (Heffer, 1921).

  • Wachsmuth, H. R., Weninger, S. N. & Duca, F. A. Role of the gut–brain axis in energy and glucose metabolism. Exp. Mol. Med. 54, 377–392 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Veerakumar, A., Yung, A. R., Liu, Y. & Krasnow, M. A. Molecularly defined circuits for cardiovascular and cardiopulmonary control. Nature 606, 739–746 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lovelace, J. W. et al. Vagal sensory neurons mediate the Bezold–Jarisch reflex and induce syncope. Nature 623, 387–396 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xiao, R. & Xu, X. Z. S. Temperature sensation: from molecular thermosensors to neural circuits and coding principles. Annu. Rev. Physiol. 83, 205–230 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mota, C. M. D. & Madden, C. J. Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands. Nat. Rev. Neurosci. 25, 143–158 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chang, R. B., Strochlic, D. E., Williams, E. K., Umans, B. D. & Liberles, S. D. Vagal sensory neuron subtypes that differentially control breathing. Cell 161, 622–633 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen, C. et al. Long-term imaging of dorsal root ganglia in awake behaving mice. Nat. Commun. 10, 3087 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Goldstein, N. et al. Hypothalamic detection of macronutrients via multiple gut–brain pathways. Cell Metab. 33, 676–687.e5 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ichiki, T. et al. Sensory representation and detection mechanisms of gut osmolality change. Nature 602, 468–474 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wolfson, R. L. et al. DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon. Cell 186, 3368–3385.e18 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bayrer, J. R. et al. Gut enterochromaffin cells drive visceral pain and anxiety. Nature 616, 137–142 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Langley, J. N. Sketch of the progress of discovery in the eighteenth century as regards the autonomic nervous system. J. Physiol. 50, 225–258 (1916).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Guyenet, P. G. The sympathetic control of blood pressure. Nat. Rev. Neurosci. 7, 335–346 (2006).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Goldstein, D. S. Differential responses of components of the autonomic nervous system. Handb. Clin. Neurol. 117, 13–22 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Lin, E. E., Scott-Solomon, E. & Kuruvilla, R. Peripheral innervation in the regulation of glucose homeostasis. Trends Neurosci. 44, 189–202 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nakamura, K., Nakamura, Y. & Kataoka, N. A hypothalamomedullary network for physiological responses to environmental stresses. Nat. Rev. Neurosci. 23, 35–52 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tao, J. et al. Highly selective brain-to-gut communication via genetically defined vagus neurons. Neuron 109, 2106–2115.e4 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sharkey, K. A., Williams, R. G. & Dockray, G. J. Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing. Gastroenterology 87, 914–921 (1984).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Trudrung, P., Furness, J. B., Pompolo, S. & Messenger, J. P. Locations and chemistries of sympathetic nerve cells that project to the gastrointestinal tract and spleen. Arch. Histol. Cytol. 57, 139–150 (1994).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Quinson, N., Robbins, H. L., Clark, M. J. & Furness, J. B. Locations and innervation of cell bodies of sympathetic neurons projecting to the gastrointestinal tract in the rat. Arch. Histol. Cytol. 64, 281–294 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Torres, H. et al. Sympathetic innervation of the mouse kidney and liver arising from prevertebral ganglia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 321, R328–R337 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chan, K. L., Poller, W. C., Swirski, F. K. & Russo, S. J. Central regulation of stress-evoked peripheral immune responses. Nat. Rev. Neurosci. 24, 591–604 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Scott-Solomon, E., Boehm, E. & Kuruvilla, R. The sympathetic nervous system in development and disease. Nat. Rev. Neurosci. 22, 685–702 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kuntz, A. & Jacobs, M. W. Components of periarterial extensions of celiac and mesenteric plexuses. Anat. Rec. 123, 509–520 (1955).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Muller, P. A. et al. Microbiota modulate sympathetic neurons via a gut–brain circuit. Nature 583, 441–446 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Eng, C.-H. L. et al. Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH. Nature 568, 235–239 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Furlan, A. et al. Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nat. Neurosci. 19, 1331–1340 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Mapps, A. A. et al. Diversity of satellite glia in sympathetic and sensory ganglia. Cell Rep. 38, 110328 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kumari, R. et al. Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice. Cell Rep. 43, 113674 (2024).

  • Lindh, B. et al. Topography of NPY-, somatostatin-, and VIP-immunoreactive, neuronal subpopulations in the guinea pig celiac-superior mesenteric ganglion and their projection to the pylorus. J. Neurosci. 6, 2371–2383 (1986).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lindh, B., Hökfelt, T. & Elfvin, L. G. Distribution and origin of peptide-containing nerve fibers in the celiac superior mesenteric ganglion of the guinea-pig. Neuroscience 26, 1037–1071 (1988).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Miolan, J. P. & Niel, J. P. The mammalian sympathetic prevertebral ganglia: integrative properties and role in the nervous control of digestive tract motility. J. Auton. Nerv. Syst. 58, 125–138 (1996).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kaestner, C. L., Smith, E. H., Peirce, S. G. & Hoover, D. B. Immunohistochemical analysis of the mouse celiac ganglion: an integrative relay station of the peripheral nervous system. J. Comp. Neurol. 527, 2742–2760 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Sun, C., Zhang, T., Liu, C., Gu, S. & Chen, Y. Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb. Genesis 51, 515–522 (2013).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hama, H. et al. ScaleS: an optical clearing palette for biological imaging. Nat. Neurosci. 18, 1518–1529 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Browning, K. N. & Travagli, R. A. Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions. Compr. Physiol. 4, 1339–1368 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Beckh, K. & Arnold, R. Regulation of bile secretion by sympathetic nerves in perfused rat liver. Am. J. Physiol. 261, G775–G780 (1991).

    CAS 
    PubMed 

    Google Scholar 

  • Ali, A. E., Rutishauser, S. C. & Case, R. M. Pancreatic and biliary secretion in the anesthetized Syrian golden hamster in response to secretin, cholecystokinin-octapeptide, bombesin, and carbachol. Pancreas 5, 314–322 (1990).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Marliss, E. B. et al. Glucagon release induced by pancreatic nerve stimulation in the dog. J. Clin. Invest. 52, 1246–1259 (1973).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ahrén, B., Veith, R. C. & Taborsky, G. J. Sympathetic nerve stimulation versus pancreatic norepinephrine infusion in the dog: 1). Effects on basal release of insulin and glucagon. Endocrinology 121, 323–331 (1987).

    Article 
    PubMed 

    Google Scholar 

  • Rao, M. & Gershon, M. D. The bowel and beyond: the enteric nervous system in neurological disorders. Nat. Rev. Gastroenterol. Hepatol. 13, 517–528 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Servin-Vences, M. R. et al. PIEZO2 in somatosensory neurons controls gastrointestinal transit. Cell 186, 3386–3399.e15 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cannon, W. B. The Wisdom of the Body 2nd edn (Norton & Co., 1939).

  • Seals, D. R. & Victor, R. G. Regulation of muscle sympathetic nerve activity during exercise in humans. Exerc. Sport Sci. Rev. 19, 313–349 (1991).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Jänig, W. & McLachlan, E. M. Characteristics of function-specific pathways in the sympathetic nervous system. Trends Neurosci. 15, 475–481 (1992).

    Article 
    PubMed 

    Google Scholar 

  • Morrison, S. F. Differential control of sympathetic outflow. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R683–R698 (2001).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Gonsalvez, D. G., Kerman, I. A., McAllen, R. M. & Anderson, C. R. Chemical coding for cardiovascular sympathetic preganglionic neurons in rats. J. Neurosci. 30, 11781–11791 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wang, M., Wang, Q. & Whim, M. D. Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia. Proc. Natl Acad. Sci. USA 113, E3029–E3038 (2016).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Pool, A.-H. et al. The cellular basis of distinct thirst modalities. Nature 588, 112–117 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Balakrishnan, G., Zhao, A., Sabuncu, M. R., Guttag, J. and Dalca, A. V. VoxelMorph: a learning framework for deformable medical image registration. IEEE Trans. Med. Imaging 38, 1788–1800 (2019).

  • Dalca, A. V., Rakic, M., Guttag, J. & Sabuncu, M. in Advances in Neural Information Processing Systems Vol. 32 (Curran Associates, Inc., 2019).

  • Carrier, G. O. & Ikeda, S. R. TTX-sensitive Na+ channels and Ca2+ channels of the L- and N-type underlie the inward current in acutely dispersed coeliac-mesenteric ganglia neurons of adult rats. Pflugers Arch. 421, 7–16 (1992).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Pool, A.-H., Poldsam, H., Chen, S., Thomson, M. & Oka, Y. Recovery of missing single-cell RNA-sequencing data with optimized transcriptomic references. Nat. Methods 20, 1506–1515 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression data analysis. Genome Biol. 19, 15 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411–420 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Korsunsky, I. et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat. Methods 16, 1289–1296 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wang, T. & Oka, Y. Celiac-superior mesenteric ganglia (CG-SMG) innervation. Zenodo https://doi.org/10.5281/zenodo.13306861 (2024).

  • Tongtong, W. & Oka, Y. Celiac-superior mesenteric ganglia (CG-SMG) spatial transcriptomics. Zenodo https://doi.org/10.5281/zenodo.13883320 (2024).

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